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- Email: info@nsjbio.com
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Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear (By similarity).
Titration of the VANGL2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
This VANGL2 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 376-410 amino acids from human VANGL2.
Aliquot the VANGL2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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