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- Tel: 858.663.9055
- Email: info@nsjbio.com
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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
The stated application concentrations are suggested starting points. Titration of the UBA3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 415-445 from the human protein was used as the immunogen for the UBA3 antibody.
Aliquot the UBA3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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