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The protein encoded by this gene is a cytosolic enzyme that catalyzes the addition of a gamma-phosphate group to thymidine. This creates dTMP and is the first step in the biosynthesis of dTTP, which is one component required for DNA replication. The encoded protein, whose levels fluctuate depending on the cell cycle stage, can act as a low activity dimer or a high activity tetramer. High levels of this protein have been used as a biomarker for diagnosing and categorizing many types of cancers. [RefSeq]
Optimal dilution of the Thymidine Kinase 1 antibody should be determined by the researcher.
A synthetic peptide specific to human Thymidine Kinase 1 was used as the immunogen for the TK1 antibody.
Store the TK1 antibody at -20oC.
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