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- Tel: 858.663.9055
- Email: info@nsjbio.com
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SUMO2 and SUMO3 are members of the SUMO (small ubiquitin-like modifier) protein family. This protein family functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. In vertebrates, three members of the SUMO family have been described, SUMO 1 and the functionally distinct homologues SUMO 2 and SUMO 3. SUMO modification sites present in the N terminal regions of SUMO 2 and SUMO 3 are utilized by SAE1/SAE2 (SUMO E1) and Ubc9 (SUMO E2) to form polymeric chains of SUMO 2 and SUMO 3 on protein substrates, a property not shared by SUMO 1.
Titration of the SUMO-3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 38-64 from the human protein was used as the immunogen for this SUMO-3 antibody.
Aliquot the SUMO-3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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