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- Tel: 858.663.9055
- Email: info@nsjbio.com
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This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants.
Titration of the SIRT5 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 99-127 from the human protein was used as the immunogen for this SIRT5 antibody.
Aliquot the SIRT5 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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