• Tel: 858.663.9055
  • SeparatorEmail: info@nsjbio.com
  • Tel: 858.663.9055
  • Email: info@nsjbio.com
Order
Home >> Antibodies >> SHP2 Antibody / PTPN11

SHP2 Antibody / PTPN11 (F51157)

NSJ bio Image Pdf Image
  Catalog No Formulation Size Price (USD)  
Image F51157-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F51157-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
Bulk quote request
Fluorescent image of HeLa cells stained with SHP2 antibody. Alexa Fluor 488 conjugated secondary (green) was used. SHP2 immunoreactivity is localized to nucleolus and cytoplasm strongly and nucleus weakly.
›
Fluorescent image of HeLa cells stained with SHP2 antibody. Alexa Fluor 488 conjugated secondary (green) was used. SHP2 immunoreactivity is localized to nucleolus and cytoplasm strongly and nucleus weakly.
Western blot analysis of SHP2 antibody and 293 cell lysate either nontransfected (Lane 1) or transiently transfected with the PTPN11/SHP2 gene (2). Predicted molecular weight: ~68kDa.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Purified
UniProt Q06124
Applications Immunofluorescence : 1:10-1:50
Western blot : 1:1000
Limitations This SHP2 antibody is available for research use only.
Review this product on BioCompare and get a $20 Amazon gift card

Related Products

  • Applications : WB, IHC-P
    Reactivity : Human
  • Applications : WB
    Reactivity : Human, Mouse, Rat
  • Applications : WB, IHC, FACS, ELISA
    Reactivity : Human
    Pred. Reactivity : Chicken, Mouse, Rat
  • Applications : WB, IHC, ELISA (peptide)
    Reactivity : Human, Mouse
    Pred. Reactivity : Cow, Pig, Rat
  • Applications : WB, IHC-P
    Reactivity : Human, Mouse, Rat

Description

SHP2, also known as PTPN11, is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in the gene are a cause of Noonan syndrome as well as acute myeloid leukemia.

Application Notes

Titration of the SHP2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

This SHP2 antibody was produced from rabbits immunized with a recombinant protein of partial human SHP2.

Storage

Aliquot the SHP2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Related Products

   1.   View all SHP2 antibodies

Cross
Bulk Quote Request Form
Name*:
Organization*:
Email*:
Phone Number*:
Catalog No.*:
Comments and Specifics(amount, formulation, etc.)*:
Validation code: Captchapackage Image


Can't read the image? click here to refresh.
    *required field

Your bulk quote request has been submitted successfully!

Please contact us if you have any questions.