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- Tel: 858.663.9055
- Email: info@nsjbio.com
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This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified.
The stated application concentrations are suggested starting points. Titration of the SERPINI1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 19-45 from the human protein was used as the immunogen for the SERPINI1 antibody.
Aliquot the SERPINI1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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