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Home >> Antibodies >> Regulator of Chromosome Condensation Antibody / RCC1 / CHC1

Regulator of Chromosome Condensation Antibody / RCC1 / CHC1 [clone 7B5D2] (RQ7122)

  Catalog No Formulation Size Price (USD)  
Image RQ7122 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of human 1) 293T, 2) A431, 3) HepG2 and 4) Raji cell lysate with Regulator of Chromosome Condensation antibody. Predicted molecular weight ~45 kDa.
Availability 1-3 business days
Species Reactivity Human
Format Antigen affinity purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1
Clone Name 7B5D2
Purity Antigen affinity purified
Buffer Lyophilized from 1X PBS with 2% Trehalose
UniProt P18754
Localization Nuclear, cytoplasmic
Applications Western blot : 0.5-1ug/ml
Limitations This Regulator of Chromosome Condensation antibody is available for research use only.
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Description

Regulator of Chromosome Condensation, also named RCC1, SNHG3-RCC1 and CHC1 (Chromosome condensation protein 1), promotes the exchange of ran-bound gdp by gtp. It is involved in the regulation of onset of chromosome condensation in the S-phase. Phosphorylation of RCC1 on serines located in or near its nuclear localization signal activates RCC1 to generate RanGTP on mitotic chromosomes, which is required for spindle assembly and chromosome segregation.

Application Notes

Optimal dilution of the Regulator of Chromosome Condensation antibody should be determined by the researcher.

Immunogen

Recombinant human protein (amino acids A14-S421) was used as the immunogen for the Regulator of Chromosome Condensation antibody.

Storage

After reconstitution, the Regulator of Chromosome Condensation antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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