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Home >> Antibodies >> RASGRP1 Antibody / RAS guanyl-releasing protein 1

RASGRP1 Antibody / RAS guanyl-releasing protein 1 (RQ7733)

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  Catalog No Formulation Size Price (USD)  
Image RQ7733 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Flow cytometry testing of human U-2 OS cells with RASGRP1 antibody at 1ug/million cells (blocked with goat sera); Red=cells alone, Green=isotype control, Blue= RASGRP1 antibody.
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Flow cytometry testing of human U-2 OS cells with RASGRP1 antibody at 1ug/million cells (blocked with goat sera); Red=cells alone, Green=isotype control, Blue= RASGRP1 antibody.
Flow cytometry testing of human MCF7 cells with RASGRP1 antibody at 1ug/million cells (blocked with goat sera); Red=cells alone, Green=isotype control, Blue= RASGRP1 antibody.
Western blot testing of human 1) Jurkat, 2) 293T and 3) U-87 MG cell lysate with RASGRP1 antibody. Predicted molecular weight ~90 kDa with multiple smaller isoforms.
Availability 1-3 business days
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity purified
Buffer Lyophilized from 1X PBS with 2% Trehalose
UniProt O95267
Applications Western blot : 0.5-1ug/ml
Flow cytometry : 1-3ug/million cells
Direct ELISA : 0.1-0.5ug/ml
Limitations This RASGRP1 antibody is available for research use only.
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Description

RAS guanyl-releasing protein 1 is a protein that in humans is encoded by the RASGRP1 gene. This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE).

Application Notes

Optimal dilution of the RASGRP1 antibody should be determined by the researcher.

Immunogen

E. coli-derived recombinant human protein (amino acids R8-Q678) was used as the immunogen for the RASGRP1 antibody.

Storage

After reconstitution, the RASGRP1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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