- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Pak7 Antibody / Pak5 (F43498)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
F43498-0.4ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.4 ml | 399 | |
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F43498-0.08ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.08 ml | 185 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse |
| Predicted Reactivity | Rat |
| Format | Antigen affinity purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Purity | Antigen affinity |
| UniProt | Q8C015 |
| Localization | Cytoplasmic |
| Applications | Western blot : 1:1000 IHC (Paraffin) : 1:10-1:50 |
| Limitations | This Pak7 antibody is available for research use only. |
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Pak7, also called Pak5, is a serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions (By similarity). [UniProt]
Titration of the Pak7 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 128-157 from the mouse protein was used as the immunogen for this Pak7 antibody.
Aliquot the Pak7 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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