- Tel: 858.663.9055
- Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Protein kinase C and casein kinase substrate in neurons protein 2 is a lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle- mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. May also play a role in the formation of caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis.
Titration of the PACSIN2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A partial recombinant protein corresponding to amino acids 250-486 from the human protein was used as the immunogen for the PACSIN2 antibody.
Aliquot the PACSIN2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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