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- Tel: 858.663.9055
- Email: info@nsjbio.com
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Myb is a transcriptional activator; DNA-binding protein that recognizes the sequence 5'-YAAC[GT]G-3'. It participates in the control of proliferation and differentiation of hematopoietic progenitor cells. Myb is a transcription factor related to Myc, and is expressed predominantly in haematopoietic cells and immature gastroepithelial cells. TRAF7 stimulates the sumoylation of Myb at Lys-523 and Lys-499, which are the same sites as those used for PIASy-induced sumoylation. A correlation has been established between reduction in sumoylation of Myb and increase in transcriptional activation. Negative influence on transactivation properties by the negative regulatory domain region of c-Myb depends on upon sumoylation.
Titration of the Myb antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 506-534 from the human protein was used as the immunogen for this Myb antibody.
Aliquot the Myb antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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