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- Tel: 858.663.9055
- Email: info@nsjbio.com
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FRAP1/mTOR belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. It is a part of the TORC2 complex which plays a critical role in AKT1 Ser-473 phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization.
Titration of the mTOR antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 2459-2488 from the human protein was used as the immunogen for this mTOR antibody.
Aliquot the mTOR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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