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- Email: info@nsjbio.com
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This gene encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif, and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid cells. Multiple transcript variants encoding different isoforms have been found for this gene.
The stated application concentrations are suggested starting points. Titration of the MPP1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 301-327 from the human protein was used as the immunogen for the MPP1 antibody.
Aliquot the MPP1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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