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Home >> Antibodies >> MMP7 Antibody

MMP7 Antibody (F49501)

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  Catalog No Formulation Size Price (USD)  
Image F49501-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F49501-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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Confocal immunofluorescent analysis of MMP7 antibody with 293 cells followed by Alexa Fluor 488-conjugated goat rabbit lgG (green). DAPI was used as a nuclear counterstain (blue).
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Confocal immunofluorescent analysis of MMP7 antibody with 293 cells followed by Alexa Fluor 488-conjugated goat rabbit lgG (green). DAPI was used as a nuclear counterstain (blue).
IHC analysis of FFPE human breast carcinoma tissue stained with the MMP7 antibody
Western blot testing of MMP7 antibody and 293 cell lysate. Predicted molecular weight ~30kDa.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Purified
UniProt P09237
Applications Western blot : 1:1000
IHC (Paraffin) : 1:50-1:100
Immunofluorescence : 1:10-1:50
Limitations This MMP7 antibody is available for research use only.
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Description

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP7 degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

Application Notes

Titration of the MMP7 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 117-146 from the human protein was used as the immunogen for this MMP7 antibody.

Storage

Aliquot the MMP7 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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