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Home >> Antibodies >> MITA Antibody / Mediator of IRF3 activation / STING1 / ERIS

MITA Antibody / Mediator of IRF3 activation / STING1 / ERIS [clone STING1/8129R] (V5100)

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  Catalog No Formulation Size Price (USD)  
Image V5100-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V5100-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V5100SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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IHC staining of FFPE human tonsil tissue with MITA antibody (clone STING1/8129R). Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
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IHC staining of FFPE human tonsil tissue with MITA antibody (clone STING1/8129R). Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE human spleen tissue with MITA antibody (clone STING1/8129R). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE human serous ovarian carcinoma with MITA antibody (clone STING1/8129R). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE human prostate carcinoma tissue with MITA antibody (clone STING1/8129R). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE human mammary cancer with MITA antibody (clone STING1/8129R). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE human renal cell carcinoma with MITA antibody (clone STING1/8129R). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Recombinant Rabbit Monoclonal
Isotype Rabbit IgG, kappa
Clone Name STING1/8129R
Purity Protein A/G affinity
UniProt Q86WV6
Localization Cytoplasm
Applications Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Limitations This MITA antibody is available for research use only.
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Description

TMEM173 (transmembrane protein 173), also called MITA (Mediator of IRF3 activation), STING1 and ERIS, is a 379 amino acid protein encoded by a gene mapping to human chromosome 5. With 181 million base pairs encoding around 1,000 genes, chromosome 5 is about 6% of human genomic DNA. It is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5 associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome. Deletion of 5q or chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.

Application Notes

Optimal dilution of the MITA antibody should be determined by the researcher.

Immunogen

A recombinant partial protein sequence (within amino acids 190-290) from the human protein was used as the immunogen for the MITA antibody.

Storage

Aliquot the MITA antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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