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Home >> Antibodies >> mGluR5 Antibody / Glutamate Metabotropic Receptor 5 / GRM5

mGluR5 Antibody / Glutamate Metabotropic Receptor 5 / GRM5 (RQ7664)

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Image RQ7664 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of 1) human U-87 MG, 2) human 293T and 3) rat C6 cell lysate with mGluR5 antibody. Predicted molecular weight ~132 kDa but may be observed at higher molecular weights due to glycosylation.
Western blot testing of 1) human U-87 MG, 2) human 293T and 3) rat C6 cell lysate with mGluR5 antibody. Predicted molecular weight ~132 kDa but may be observed at higher molecular weights due to glycosylation.
Availability 1-3 business days
Species Reactivity Human, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity purified
Buffer Lyophilized from 1X PBS with 2% Trehalose
UniProt P41594
Applications Western blot : 0.5-1ug/ml
Direct ELISA : 0.1-0.5ug/ml
Limitations This mGluR5 antibody is available for research use only.
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Description

Metabotropic glutamate receptor 5 is a G protein-coupled receptor that in humans is encoded by the GRM5 gene. It is mapped to 11q14.2-q14.3. This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants.

Application Notes

Optimal dilution of the mGluR5 antibody should be determined by the researcher.

Immunogen

E. coli-derived recombinant human protein (amino acids K443-S1050) was used as the immunogen for the mGluR5 antibody.

Storage

After reconstitution, the mGluR5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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