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Home >> Antibodies >> MeCP2 Antibody

MeCP2 Antibody (F48099)

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  Catalog No Formulation Size Price (USD)  
Image F48099-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
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F48099-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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MeCP2 antibody flow cytometric analysis of MDA-MB435 cells (green) compared to a <a href=../search_result.php?search_txt=n1001>negative control</a> (blue). FITC-conjugated goat-anti-rabbit secondary Ab was used for the analysis.
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MeCP2 antibody flow cytometric analysis of MDA-MB435 cells (green) compared to a negative control (blue). FITC-conjugated goat-anti-rabbit secondary Ab was used for the analysis.
Western blot analysis of MeCP2 antibody and 293 cell lysate (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (2) with the MeCP2 gene. Observed molecular weight: ~55 kDa and ~75 kDa.
Availability 1-3 business days
Species Reactivity Human
Predicted Reactivity Primate
Format Purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Purified
UniProt P51608
Applications Western blot : 1:1000
Flow Cytometry : 1:10-1:50
Limitations This MeCP2 antibody is available for research use only.
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Description

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of some cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.

Application Notes

Titration of the MeCP2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 1-30 from the human protein was used as the immunogen for this MeCP2 antibody.

Storage

Aliquot the MeCP2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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