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Home >> Antibodies >> Major Vault Protein Antibody

Major Vault Protein Antibody [clone 1014] (V3042)

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  Catalog No Formulation Size Price (USD)  
Image V3042-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 519
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V3042-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 229
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V3042SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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Immunofluorescent staining of human A549 cells with Major Vault Protein antibody (green, clone 1014) and Reddot nuclear stain (red).
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Immunofluorescent staining of human A549 cells with Major Vault Protein antibody (green, clone 1014) and Reddot nuclear stain (red).
Western blot testing of HeLa cell lysate with Major Vault Protein antibody (clone 1014). Observed molecular weight: 104~110 kDa.
SDS-PAGE Analysis of Purified, BSA-Free Major Vault Protein Antibody (clone 1014). Confirmation of Integrity and Purity of the Antibody.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name 1014
Purity Protein G affinity chromatography
UniProt Q14764
Localization Cytoplasmic, nuclear
Applications Western blot : 1-2ug/ml
Immunofluorescence : 1-2ug/ml
Limitations This Major Vault Protein antibody is available for research use only.
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Description

Recognizes a protein of 104kDa-110kDa, characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for >70% of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy.

Application Notes

Optimal dilution of the Major Vault Protein antibody should be determined by the researcher.

Immunogen

Proteins precipitated from human breast cancer MCF-7 cells were used as the immunogen for the Major Vault Protein antibody.

Storage

Store the Major Vault Protein antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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