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Home >> Antibodies >> LH beta Antibody / Luteinizing Hormone beta

LH beta Antibody / Luteinizing Hormone beta [clone rLHb/1613] (V9669)

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  Catalog No Formulation Size Price (USD)  
Image V9669-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V9669-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V9669SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
Microvalidated Recmousemono
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IHC staining of FFPE human pituitary tissue with LH beta antibody (clone rLHb/1613). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
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IHC staining of FFPE human pituitary tissue with LH beta antibody (clone rLHb/1613). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free LH beta antibody (clone rLHb/1613) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Recombinant Mouse Monoclonal
Isotype Mouse IgG1, kappa
Clone Name rLHb/1613
Purity Protein A/G affinity
UniProt P01229
Localization Cytoplasm, Secreted
Applications Immunohistochemistry (FFPE) : 1-2ug/ml
Limitations This LH beta antibody is available for research use only.
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Description

LH has a beta subunit of 121 amino acids (LHB) that confers its specific biologic action and is responsible for interaction with the LH receptor. This beta subunit contains the same amino acids in sequence as the beta subunit of hCG and both stimulate the same receptor; however, the hCG beta subunit contains an additional 24 amino acids and the hormones differ in the composition of their sugar moieties.LH is synthesized and secreted by gonadotrophs in the anterior lobe of the pituitary gland. In concert with the other pituitary gonadotropin follicle-stimulating hormone (FSH), it is necessary for proper reproductive function. In the female, an acute rise of LH levels triggers ovulation. In the male, where LH has also been called Interstitial Cell-Stimulating Hormone (ICSH), it stimulates Leydig cell production of testosterone. LH is a useful marker in classification of pituitary tumors and the study of pituitary disease.

Application Notes

Optimal dilution of the LH beta antibody should be determined by the researcher.

Immunogen

Recombinant full-length human protein was used as the immunogen for the LH beta antibody.

Storage

Aliquot the LH beta antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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