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- Tel: 858.663.9055
- Email: info@nsjbio.com
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Interleukin 10 (IL10) is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immuno-regulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immuno-regulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
Optimal dilution of the Interleukin 10 antibody should be determined by the researcher.
Recombinant full-length human Interleukin 10 (IL10) protein was used as the immunogen for the Interleukin 10 antibody.
Aliquot the Interleukin 10 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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