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- Tel: 858.663.9055
- Email: info@nsjbio.com
The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion.
The stated application concentrations are suggested starting points. Titration of the Inhibin beta B chain antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 369-397 from the human protein was used as the immunogen for the Inhibin beta B chain antibody.
Aliquot the Inhibin beta B chain antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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