- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
IL-11 Antibody (N-Terminal Region) (F54094)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
F54094-0.2ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.2 ml | 399 | |
|
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F54094-0.05ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.05 ml | 185 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Antigen affinity purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Purity | Antigen affinity |
| UniProt | P20809 |
| Applications | Western Blot : 1:2000 |
| Limitations | This IL-11 antibody is available for research use only. |
|
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Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed: 2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. [UniProt]
The stated application concentrations are suggested starting points. Titration of the IL-11 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 27-61 from human IL-11 was used as the immunogen for the IL-11 antibody.
Aliquot the IL-11 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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