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Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves. Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). [UniProt]
Optimal dilution of the IFNAR1 antibody should be determined by the researcher.
A synthetic peptide from human Interferon Receptor alpha was used as the immunogen for the IFNAR1 antibody.
Store the IFNAR1 antibody at -20oC.
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