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- Tel: 858.663.9055
- Email: info@nsjbio.com
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Fibrinogen gamma chain, also known as FGG, is a human gene found on chromosome 4. The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in transcript variants encoding different isoforms.
Optimal dilution of the Fibrinogen gamma chain antibody should be determined by the researcher.
Amino acids 133-163 (IRYLQEIYNSNNQKIVNLKEKVAQLEAQCQE-human) were used as the immunogen for the Fibrinogen gamma chain antibody.
After reconstitution, the Fibrinogen gamma chain antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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