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- Tel: 858.663.9055
- Email: info@nsjbio.com
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FIBG is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in its gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia.
The stated application concentrations are suggested starting points. Titration of the FGG antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 420-449 from the human protein was used as the immunogen for the FGG antibody.
Aliquot the FGG antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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