• Tel: 858.663.9055
  • SeparatorEmail: info@nsjbio.com
  • Tel: 858.663.9055
  • Email: info@nsjbio.com
Order
Home >> Antibodies >> EED Antibody

EED Antibody (F53203)

NSJ bio Image Pdf Image
  Catalog No Formulation Size Price (USD)  
Image F53203-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F53203-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
Bulk quote request
Western blot testing of EED antibody at 1:1000 dilution. Lane 1: A431 lysate; 2: NIH3T3 lysate; Predicted molecular weight: 50 kDa (isoform 1), 53 kDa (isoform 2), 46 kDa (isoform 3).
Western blot testing of EED antibody at 1:1000 dilution. Lane 1: A431 lysate; 2: NIH3T3 lysate; Predicted molecular weight: 50 kDa (isoform 1), 53 kDa (isoform 2), 46 kDa (isoform 3).
Availability 1-3 business days
Species Reactivity Human, Mouse
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt Q921E6
Applications Western blot : 1:1000
Limitations This EED antibody is available for research use only.
Review this product on BioCompare and get a $20 Amazon gift card

Related Products

Description

Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark (By similarity). The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8. Plays a role in X chromosome inactivation (XCI), in which one of the two X chromosomes in female mammals is transcriptionally silenced to equalize X-linked gene dosage with XY males. Required for stable maintenance of XCI in both embryonic and extraembryonic tissues. May prevent transcriptional activation of facultative heterochromatin during differentiation. Required for development of secondary trophoblast giant cells during placental development. May regulate hippocampal synaptic plasticity in the developing brain.

Application Notes

Titration of the EED antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

This EED antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 269-303 amino acids from the central region of mouse Eed.

Storage

Aliquot the EED antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Related Products

   1.   View all EED antibodies

Cross
Bulk Quote Request Form
Name*:
Organization*:
Email*:
Phone Number*:
Catalog No.*:
Comments and Specifics(amount, formulation, etc.)*:
Validation code: Captchapackage Image


Can't read the image? click here to refresh.
    *required field

Your bulk quote request has been submitted successfully!

Please contact us if you have any questions.