- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Dtr Antibody / Hbegf (RQ8280)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
RQ8280 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 429 |
|
| Availability | 1-3 business days |
| Species Reactivity | Mouse, Rat |
| Format | Antigen affinity purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity purified |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | Q06186 |
| Applications | Western blot : 0.5-1ug/ml ELISA : 0.1-0.5ug/ml |
| Limitations | This Dtr antibody is available for research use only. |
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Heparin-binding EGF-like growth factor (HB-EGF), also called Diphtheria toxin receptor (Dtr) is a member of the EGF family of proteins that in humans is encoded by the HBEGF gene. Enables epidermal growth factor receptor binding activity; growth factor activity; and heparin binding activity. Involved in positive regulation of keratinocyte migration; positive regulation of smooth muscle cell proliferation; and wound healing, spreading of epidermal cells. Acts upstream of or within several processes, including epidermal growth factor receptor signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; and regulation of heart contraction. Located in extracellular space. Is integral component of plasma membrane. Is expressed in several structures, including branchial arch; heart; oral region gland; telencephalon; and tooth. Human ortholog(s) of this gene implicated in glomerulosclerosis and perinatal necrotizing enterocolitis. Orthologous to human HBEGF (heparin binding EGF like growth factor).
Optimal dilution of the Dtr antibody should be determined by the researcher.
An E.coli-derived mouse recombinant protein (D63-L148) was used as the immunogen for the Dtr antibody.
After reconstitution, the Dtr antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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