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The neuronal migration protein Doublecortin is a microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration. [UniProt]
Optimal dilution of the Doublecortin antibody should be determined by the researcher.
A synthetic peptide specific to human Doublecortin / DCX was used as the immunogen for the Doublecortin antibody.
Store the Doublecortin antibody at -20oC.
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