- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
DKK2 Antibody [clone 1833CT856.7.20] (F54135)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
F54135-0.2ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.2 ml | 399 | |
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F54135-0.05ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.05 ml | 185 |
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| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse |
| Format | Purified |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | 1833CT856.7.20 |
| Purity | Protein G purified |
| UniProt | Q9UBU2 |
| Applications | Western Blot : 1:2000 |
| Limitations | This DKK2 antibody is available for research use only. |
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Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). [UniProt]
The stated application concentrations are suggested starting points. Titration of the DKK2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Recombinant human DKK2 was used as the immunogen for the DKK2 antibody.
Aliquot the DKK2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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