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Home >> Antibodies >> Desmoglein 2 Antibody

Desmoglein 2 Antibody (R30636)

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  Catalog No Formulation Size Price (USD)  
Image R30636 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Immunofluorescent staining of FFPE human MCF7 cells with Desmoglein 2 antibody (green) and DAPI (blue).
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Immunofluorescent staining of FFPE human MCF7 cells with Desmoglein 2 antibody (green) and DAPI (blue).
IHC staining of FFPE human lung cancer with Desmoglein 2 antibody. HIER: boil tissue sections in pH8 EDTA buffer, for 20 min and allow to cool before testing.
IHC staining of FFPE human breast cancer with Desmoglein 2 antibody. HIER: boil tissue sections in pH8 EDTA buffer, for 20 min and allow to cool before testing.
IHC staining of FFPE rat intestine with Desmoglein 2 antibody. HIER: boil tissue sections in pH8 EDTA buffer, for 20 min and allow to cool before testing.
Western blot testing of human 1) K562, 2) HeLa, 3) HepG2, 4) A549, 5) Caco-2, 6) SW620, 7) rat liver and 8) mouse liver lysate with Desmoglein 2 antibody. Expected molecular weight: 122-160 kDa depending on glycosylation level.
Flow cytometry testing of human 293T cells with Desmoglein 2 antibody at 1ug/million cells (blocked with goat sera); Red=cells alone, Green=isotype control, Blue= Desmoglein 2 antibody.
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
UniProt Q14126
Localization Cytoplasm, membrane (cell junctions)
Applications Western blot : 0.5-1ug/ml
IHC (FFPE) : 0.5-1ug/ml
Immunofluorescence : 2-4ug/ml
Flow cytometry : 1-3ug/million cells
Limitations This Desmoglein 2 antibody is available for research use only.
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Description

Desmoglein-2 is a protein that in humans is encoded by the DSG2 gene. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines. Mutations in DSG2 display a high degree of penetrance. Disease expression was of variable severity with LV involvement a prominent feature. The low prevalence of classical ECG changes highlights the need to expand current diagnostic criteria to take account of LV disease, childhood disease expression, and incomplete penetrance.

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the Desmoglein 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

An amino acid sequence from the C-terminus of human Desmoglein 2 (STRVTKHSTVQHSYS) was used as the immunogen for this Desmoglein 2 antibody.

Storage

After reconstitution, the Desmoglein 2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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