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- Tel: 858.663.9055
- Email: info@nsjbio.com
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Cytochrome P450 17A1, also called steroid 17a-monooxygenase, is an enzyme of the hydroxylase type that in humans is encoded by the CYP17A1 gene on chromosome 10. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia.
Optimal dilution of the CYP17A1 antibody should be determined by the researcher.
Amino acids 383-419 (EFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLN-human) were used as the immunogen for the CYP17A1 antibody.
After reconstitution, the CYP17A1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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