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- Tel: 858.663.9055
- Email: info@nsjbio.com
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Cathepsin D is a ubiquitously expressed lysosomal aspartyl protease involved in the normal degradation of proteins. It is synthesized as an inactive 43kDa preprocathepsin D that is cleaved and glycosylated to form a 46kDa procathepsin D and then further cleaved to produce 28kDa and 15kDa subunits (heavy and light chains, respectively). Cathepsin D exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimers disease.
Optimal dilution of the CTSD antibody should be determined by the researcher.
Purified His-tagged CTSD protein was used as the immunogen for the CTSD antibody.
Aliquot the CTSD antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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