- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Cortactin Antibody [clone 401CT8.6.3] (F53608)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
F53608-0.1ML | In ascites with 0.09% sodium azide | 0.1 ml | 399 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Ascites |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgM |
| Clone Name | 401CT8.6.3 |
| Purity | Ascites |
| UniProt | Q14247 |
| Applications | Western blot : 1:1000-1:8000 |
| Limitations | This Cortactin antibody is available for research use only. |
|
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This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.
Titration of the Cortactin antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Purified His-tagged Cortactin protein fragment was used to produced this monoclonal Cortactin antibody.
Aliquot the Cortactin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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