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- Email: info@nsjbio.com
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. Cyclic nucleotide-gated cation channel beta-3 can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. [UniProt]
Optimal dilution of the CNGB3 antibody should be determined by the researcher.
Amino acids ESDDKPTEHYYR were used as the immunogen for this CNGB3 antibody.
Aliquot and store the CNGB3 antibody at -20oC.
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