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- Tel: 858.663.9055
- Email: info@nsjbio.com
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Claudin-2 is expressed in cation-leaky epithelia such as that of the kidney proximal tubule. Mice that are deficient in the protein have reduced reabsorption of Na+ in the proximal tubule, consistent with a role in paracellular transport. Similar results have been obtained with cultured cells, as overexpression in CLDN2 lacking cells leads to increase of permeability for small cations. Furthermore, CLDN2 has been shown to form paracellular channels for water. [Wiki]
Titration of the Claudin 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 135-164 from the human protein was used as the immunogen for this Claudin 2 antibody.
Aliquot the Claudin 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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