- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CDK4 Antibody [clone 3D12-A7-F11] (F54049)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
F54049-0.1ML | In PBS with 50% glycerol and 0.03% ProClin 300 | 0.1 ml | 399 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse lgG1 |
| Clone Name | 3D12-A7-F11 |
| Purity | Protein G affinity |
| UniProt | P11802 |
| Applications | Western blot : 1:500 |
| Limitations | This CDK4 antibody is available for research use only. |
|
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Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. [UniProt]
The stated application concentrations are suggested starting points. Titration of the CDK4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A human recombinant protein was used as the immunogen for this CDK4 antibody.
Store the CDK4 antibody at -20oC.
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