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Home >> Antibodies >> CD40 Antibody

CD40 Antibody [clone FGK45.5] (V8350)

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  Catalog No Formulation Size Price (USD)  
Image V8350-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 519
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V8350-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 229
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V8350SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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Availability 1-3 business days
Species Reactivity Mouse
Format Purified
Clonality Monoclonal (rat origin)
Isotype Rat IgG2a, kappa
Clone Name FGK45.5
Purity Protein G affinity chromatography
UniProt P27512
Applications Functional Studies (order BSA/azide-free format) :
Flow cytometry : 1-2ug/10^6 cells in 0.1ml
Immunofluorescence : 1-2ug/ml
Limitations This CD40 antibody is available for research use only.
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Description

Upon binding to its ligand CD154, CD40 acts as a costimulatory molecule for the activation of B cells, dendritic cells, monocytes, and other APCs. CD40 plays roles in B cell activation, differentiation, proliferation and Ig isotype switching as well as dendritic cell maturation. FGK4.5 can be used for blocking of CD40/CD154 interaction and forin vitroandin vivoactivation of CD40 expressing APCs. This MAb is shown to indirectly activate natural killer (NK) cells, producing significant antitumor and anti-metastatic effects. Effective in boosting immune responses against infectious agents and can potentially be used to treat chronic autoimmune inflammatory processes.

Application Notes

Optimal dilution of the CD40 antibody should be determined by the researcher.

Immunogen

Purified recombinant Mouse CD40 fusion protein was used as the immunogen for the CD40 antibody.

Storage

Store the CD40 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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