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- Tel: 858.663.9055
- Email: info@nsjbio.com
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Cathepsin L is a lysosomal cysteine proteinase with a major role in intracellular protein catabolism. It also shows the most potent collagenolytic and elastinolytic activity in vitro of any of the cathepsins. Cathepsin L has been implicated in pathologic processes including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. Human liver cathepsin L consists of a heavy chain of about 25 kD and a light chain of about 5 kD. The gene is mapped to 9q21-q22. Cathepsin L is required for endothelial progenitor cell-induced neovascularization.
The stated application concentrations are suggested starting amounts. Titration of the Cathepsin L antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Procathepsin L isolated from the human lung cancer cell line EPLC 32M1 was used as the immunogen for this Cathepsin L antibody.
After reconstitution, the Cathepsin L antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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