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- Tel: 858.663.9055
- Email: info@nsjbio.com
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Cathepsin D is a protein that in humans is encoded by the CTSD gene. This proteinase is a member of the peptidase C1 family, having a specificity similar to but narrower than that of pepsin A. It is mapped to 11p15.5. The cDNA encodes a 412-amino acid protein with 20 and 44 amino acids in a pre- and prosegment, respectively. Cathepsin D is one of the lysosomal proteinases. It is ubiquitously expressed and is involved in proteolytic degradation, cell invasion, and apoptosis. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease and it has been considered as a breast cancer tumor marker.
The stated application concentrations are suggested starting amounts. Titration of the Cathepsin D antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Mouse partial recombinant protein (AA 65-410) was used as the immunogen for this Cathepsin D antibody.
After reconstitution, the Cathepsin D antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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