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- Tel: 858.663.9055
- Email: info@nsjbio.com
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Actin-binding protein 280, or filamin, is a 280-kD protein that crosslinks actin filaments into orthogonal networks in cortical cytoplasm and participates in the anchoring of membrane proteins for the actin cytoskeleton. Remodeling of the cytoskeleton is central to the modulation of cell shape and migration. Filamin A, encoded by the FLNA gene, is a widely expressed protein that regulates reorganization of the actin cytoskeleton by interacting with integrins, transmembrane receptor complexes, and second messengers.
The stated application concentrations are suggested starting points. Titration of the Filamin A antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 1025-1054 from the human protein was used as the immunogen for the Filamin A antibody.
Aliquot the Filamin A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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